This review has mapped their pleiotropic actionsranging from redox buffering and immune modulation to epigenetic reprogrammingand highlighted encouraging preclinical synergy with radiotherapy, chemotherapy, and immunotherapy
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A viscosupplementation series costs $1,500 on average, while knee replacement surgery costs $30,000-$50,000 or more, plus extensive recovery time and potential complications
Flint and Tahrani, 2020