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what-is-glutathione-and-why-is-it-so-popular Glutathione is a powerful antioxidant naturally produced by the liver

Ye F, Kang E, Yu C, Qian X, Jacob F, Yu C, et al

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Extant studies have found that AS-IV has protective effects on the kidneys and improves renal fibrosis by enhancing the expression of phosphorylated (p-) Smad3 C/p21 and nuclear factor (erythroid-derived 2)-like 2(Nrf2)/Heme oxygenase-1(HO-1), thereby inhibiting p-Smad 3L/plasminogen activator inhibitor (PAI)-1 and reducing ROS and -SMA levels (Qin et al., 2023)