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In agreement with the noncompetitive behavior of 9 and as determined by structural superposition of the cryo-EM structure and the X-ray NADPH-TGR- complex 17 , inhibitor 9 does not sterically interfere with NADPH binding

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Ferroptosis as a p53-mediated activity during tumour suppression

Glutathione disulfide (GSSG), as gage of oxidative stress, cell proliferation, HA, TNF-, IFN-, and interleukin 1- (IL1-) were measured ( 2 O 2 induced oxidative stress, as demonstrated by an increase in GSSG, and promoted cell proliferation and cytokine release, but did not affect HA