a semi-permeable PET membrane with a pore size of 0.4 m and a thickness of 12 m (it4ip, Louvain-la-Neuve, Belgium)
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Mller, T., et al
the amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1 ,000 mg/kg, an preferably in the range of from about 1 to about l OOmg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention
Wilsons disease is the paradigmatic example: an inherited defect in the ATP7B copper-transport protein that impairs the bodys ability to remove excess copper, causing toxic copper accumulation in the liver, brain, eyes, and other organs