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However, excessive oxidative stress may impair the autophagylysosomal pathway and even lead to lysosomal membrane leakage, ultimately resulting in autophagic cell death [109, 110]

Circulating testosterone did not change in the treatment group, but significantly decreased ( p = 0.015) in controls with a significant difference over time within subjects ( p = 0.018) and between subjects ( p = 0.012)

Supplementary information is available at Cell Death & Disease s website

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