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In cartilage research, a 2015 study in a collagenase-induced knee osteoarthritis rabbit model showed that combined AOD-9604 and hyaluronic acid injections were significantly more effective than either treatment alone, with treated groups showing lower gross morphological and histopathological scores

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It has shown promise in animal studies for promoting tissue healing, including in joints, by accelerating the repair of muscles, tendons, and ligaments, reducing inflammation, and potentially aiding in pain relief