Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R et al (2020) Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice
Recommended endpoints: histology, functional assays, angiogenic markers (CD31, VEGF), and blinded scoring to reduce bias
This approach, which often involves applying a fraction of the standard dose, is designed to investigate the cellular or physiological responses without provoking the full-blown effects of the drug
In conclusion, OA pathogenesis is propelled by a metabolically dysregulated milieu, where obesity, oxidative stress, gut dysbiosis, and broader metabolic syndrome converge to create a self-perpetuating cycle of inflammation and tissue damage (Figure 1)
Combining participant observation, interviews and document analysis, embedded in a process of reflexive monitoring and evaluation, this study explores how different values, preferences and norms are negotiated over the course of creating and caring for two site-specific interventions in an inner-city neighbourhood