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[DOI] [PMC free article] [PubMed] [Google Scholar] Tsai S

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Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2 + -permeable -amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus

Nausea from tirzepatide is mediated by GLP-1 receptor activation in the area postrema (brainstem vomiting center) and peaks 2472 hours post-injection, whereas 5-amino-1MQ has no known direct emetic mechanism