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As a result, pain may return more quickly, require higher doses, or spread beyond the original sitedriving a cycle of escalating medication use without meaningful resolution (27,31)

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A decrease in flRAGE levels was observed in patients with impaired glucose tolerance and also diabetes, which was probably due to hyperglycemia-induced augmented proteolytic degradation of the RAGE subdomain mediated by disintegrins and metalloproteinases 10

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GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC