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British Journal of Haematology 99:228-236

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GLUT4, which is primarily located in striated muscle (skeletal and cardiac) and adipose tissue, plays a major role in regulating glucose uptake and overall energy balance

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Mechano Growth Factor (MGF) is produced by skeletal muscle in response to mechanical loading, eccentric exercise, or injury through alternative splicing at exon 5 of the IGF-1 gene, generating a C-terminal extension peptide (the Ec peptide) that is unique to MGF and absent from systemic IGF-1

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