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NMDA activation also requires binding of co-agonist glycine or D-serine to a distinct site on the receptor, providing an additional level of regulation

*Correspondence: Ailing Fu [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The transcription factor Nrf2 is a potent transcriptional activator that plays a central role in the inducible expression of many cytoprotective genes in response to oxidative and electrophilic stresses ( Figure 1 )

Forouzanfar et al., 2015