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Description

Such drugs may require much larger oral doses compared to parenteral (e.g., IV or sublingual) doses to achieve the same therapeutic effect

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Structural analysis demonstrates how FOXO4-DRI exploits the unique architecture of senescent cells, where FOXO4 latches onto p53 and prevents it from executing its normal pro-apoptotic function

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For example, the newly developed drug DS-8201a has higher membrane penetration and a greater drug payload than the traditional ADC drug T-DM1 91

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