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Oxygen atom: O (total electrons = 16) 1s 2 , 2s 2 , 2p x 2 , 2p y 1 , 2p z 1 Oxygen molecule: O 2 (total electrons = 16) Triplet/ground state: 1s 2 , 1s *2 , 2s 2 , 2s *2 , 2p x 2 , 2p y 2 , 2p z 2 , 2p x *1 , 2p y *1 , 2p z *0 Singlet/excited state: 1s 2 , 1s *2 , 2s 2 , 2s *2 , 2p x 2 , 2p y 2 , 2p z 2 , 2p x *2 ,2p y *0 , 2p z *0 Figure 7.10 Molecular orbital illustration of the triplet and singlet states of oxygen molecule

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Finally, we examine potential BBB-based therapeutic strategies and targets

Efficacy is measurable via laboratory analysis

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