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Consistent with an induction of oxidative stress condition, metformin increased mRNA levels of the master redox transcription factor Nrf-2 (nuclear factor erythroid-derived 2-like), as well as transsulfuration enzymes cystathionine beta-synthase and cystathionase and GSH synthesis enzymes -glutamylcysteine synthetase and glutathione synthetase

It is found that increase glutathione interacts with melanin production, the main pigment resulting in pigmentation of the skin and darker skin tone

It is always a good idea to take breaks and check in with a healthcare professional for longer-term use

doi: 10.1177/0146645317734963 52

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