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This finding provides a new link between metabolism, PP2A methylation, and key CNS proteins involved in AD pathogenesis

Transmission electron microscopy and molecular dynamics simulations demonstrated that polystyrene nanoplastics accelerate A aggregation through the formation of protein coronas, facilitating peptide fibrillization via hydrogen bonding and interactions, flow cytometry and endocytosis inhibition assays revealed that polystyrene nanoplastics impair microglial uptake of A while enhancing their own cellular internalization, leading to microglial energy exhaustion and allowing A aggregates to escape immune clearance

Additional information Translated from Uspekhi Biologicheskoi Khimii , 2025, Vol