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Two key enzymes that control histone modifications are histone methyltransferases and deacetylases, and dysregulation of these enzymes may play a role in HT pathogenesis (Pu And Zhang 2024)

(100) has provided further mechanistic insights by employing UPLC-QE-HRMS, identifying 31 prototype compounds, 60 phase I metabolites, and 23 phase II metabolites of Scrophulariae Radix in vivo