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One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)

With significant physical and emotional effects on the individual, it is additionally linked to substantial healthcare expenses

Transient erythema, pruritus, or stinging may develop at the application site, typically resolving with continued use or brief treatment interruption

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Circulating LPS and (13)--D-Glucan: A Folie Deux Contributing to HIV-Associated Immune Activation