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This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects

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2 O/Thio=90-95/2-5/2-5/1-5, volume ratio), 10 -50 were reacted 1-5 hour, remove by filter resin, add-2010 ice ether sedimentation, centrifugal collecting precipitate, with ether washing 16 time, frozen drying 1024 hours, obtain BPC157 peptide crude product

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