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116 Tobacco product manufacturers are required to submit to FDA all documents developed by the manufacturer or any other party on health, toxicological, behavioral, or physiologic effects of current or future tobacco products, including constituents, ingredients, components, and additives

16,17 The relative effect was 1.62 (95% CI: 1.18, 2.23) with no evidence of increased adverse effects (Table 1)

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Most have already tried and failed to quit

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