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Several studies show the involvement of a dysbiotic microbiome and increased gut permeability in ALS (2)

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[14] [15] In those studies, the lowest dose (600 mg) tended to be as well-tolerated as placebo, with no significant difference in adverse events compared to placebo

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This would also enable prescribers to lawfully prescribe these substances consistent with their prescribing authority under applicable state law and the broad discretion afforded to physicians under the practice of medicine