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This NCL-CLipPA approach involved reaction of the Cys residue regenerated following NCL with lipid vinyl esters to afford the cyclic lipopeptide products (Figure 10)

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Although the number of published studies is still limited, the integration of patient derived primary cells and organoids into OoC systems is emerging as a powerful approach to advance personalized therapy design and mechanistic disease investigation (145)

Fluorescent images were captured with TCS SP8 DLS confocal microscope (Leica, German)

Epidihydroquercetin ( 9 ) was quantified using a calibration curve of dihydroquercetin ( 10 ) assuming a similar ionization, and its retention time was verified using dihydroquercetin ( 10 ) epimerized as previously reported 13