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Obese mice treated with MOTS-C peptide gain less weight and exhibit better glucose tolerance versus controls

Reduce oxidative stress Low levels of glutathione have been linked to age-related diseases

The therapeutic efficacy of the nanodrug-anchored platelets will be evaluated in high-cholesterol diet-fed ApoE / mouse model of atherosclerosis, which is expected to significantly mitigate oxidative damage, modulate macrophage-driven inflammatory and immune responses, and reduce the recruitment of immune cells to the plaque sites, thereby contributing to plaque regression and fostering a more stable plaque microenvironment

doi: 10.1007/s12282-019-01012-y 107

This duration allows side effects to emerge and resolve as adaptation occurs, provides time for subtle benefits to become apparent, and establishes baseline against which to compare higher doses