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Dosing & Reconstitution Guide Educational guide for reconstitution and intermittent dosing Standard Protocol (2 mL = 2,500 IU/mL) Frequency: Inject 3 times weekly subcutaneously (e.g., Monday/Wednesday/Friday)

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Patients in a depressive bipolar state exhibit a lower neuroprotective ratio (KYNA/3-HK), which strongly correlates with elevated IFN- levels [231]

Patients who underwent LP were younger (37vs42 years), less often were women (52.1%vs65.7%), more often were from middle income countries (32.3%vs10.3%), more frequently had decreased visual acuity (26.4%vs15.9%) and papilledema (30.6%vs14.5%;Table-1)