Unlike other cell types where mitochondrial-derived H 2 O 2 activated PPP flux (Talwar et al., 2023), astrocytes needed to be incubated with microglia and LPS to stimulate nitric oxide generation that activated PPP flux ( 14 Increasing flux through the MAS, citric acid cycle, or fatty acid beta-oxidation could blunt the aging-induced oxidative shift in the mitochondrial [NAD + ]/[NADH] to slow tissue aging The combined activities of the citric acid cycle, MAS, and fatty acid beta-oxidation that generate mitochondrial NADH appear to decline to a greater extent with aging than the activity of NADH-consuming ETC complex I in neurons, leading to an oxidized mitochondrial [NAD + ]/[NADH] in aged neurons (Sato et al., 2022), while DR was shown to increase mouse brain ACO2 persulfidation by 2-fold (Kugler et al., 1988) and NAD + -dependent IDH3 (Patel, 1977), a rate-limiting step of the citric acid cycle ( + ]/[NADH] with aging
In rodents, cannabis was recently shown to modulate the myelination process
Pittenger C, Duman RS (2008) Stress, depression, and neuroplasticity: a convergence of mechanisms
It supports the production and function of white blood cells, which are essential for fighting infections and diseases
Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation
