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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

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Gtz, J., Dendritic Function of Tau Mediates Amyloid- Toxicity in Alzheimers Disease Mouse Models

doi:10.1007/978-94-007-4899-6_3

A: A 2024 clinical trial reported 34% reduction in acne lesions at 4 weeks, 58% at 8 weeks, and 72% at 12 weeks of consistent twice-daily application