Krivic A., Anic T., Seiwerth S., Huljev D., Sikiric P
doi: 10.1179/joc.2008.20.6.672 151 IwasakiAMedzhitovR
As we age, naturally occurring levels decline, and skin may gradually lose some of its youthful appearance
As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]
NAC supplementation has been studied for heavy metal detoxification, with some evidence of benefit for mercury and lead excretion, though clinical trials are limited [37]