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Drug metabolism also affects multidrug resistance in infectious diseases and in chemotherapy for cancer, and the actions of some drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a common reason for hazardous drug interactions

Tomova, A., et al

Supplementation with GSH is generally ineffective at increasing cellular glutathione levels because most human cells cannot uptake extracellular GSH due to the lack of the membrane-bound ectoenzyme -glutamyltranspeptidase (-GT) or due to an unfavorable concentration gradient across the cell membrane 10,16

Targeting specificity is another challenge, as developing therapies that induce ferroptosis or cuproptosis selectively in cancer cells without affecting healthy tissues is difficult, increasing the risk of broad cytotoxic effects

In the United States, the FDA has not approved Epithalon for medical use