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Interestingly, preclinical data has suggested that compounds thought to target downstream processes of ATXN3 aggregation have also an effect on the primary loss of PQC mechanisms, namely citalopram, creatine, and trehalose, making them great contenders for translation [148, 164, 236]

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Initial effects moderate as regulatory systems recalibrate to the new normal

[DOI] [PubMed] [Google Scholar] 64.Kataoka T., Mifune Y., Inui A., Nishimoto H., Kurosawa T., Yamaura K., Mukohara S., Matsushita T., Niikura T., Tabata Y., et al