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With hepatic injury, the half-life is prolonged to more than 4 hours [18]

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All animals were housed at Animal Experiment Center of Wenzhou Medical University under the following conditions: 3 mice/ cage (30 20 15 cm, length width height), 12 h dark/light cycle, room temperature (24 1) C, ambient humidity (50 10) %, with free access to food and water

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You may take metformin, but you may need to decrease your dose the days following your infusion