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Porphyromonas gingivalis : an overview of periodontopathic pathogen below the gum line

Experimental results revealed that molecules, 4 (P-1894047), with its complex multi-ring structure and numerous hydrogen bond acceptors, and 7 (P-2652815), characterized by a flexible, polar framework with ten hydrogen bond donors and acceptors, exhibited IC values lower than or equal to that of the control (galantamine), indicating potent inhibitory activity

In rodent studies, it has reduced neuronal damage from hippocampal ischemia-reperfusion injuries and reduced the effects of traumatic brain injury lesions