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Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening

In certain embodiments, an otic formulation or composition comprising a dye or other tracer compound eliminates the need for invasive procedures that are currently used in animal models to monitor the concentrations of drugs in the endolymph and/or perilymph

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In addition, spermidine has been shown to reduce the accumulation of ROS and enhance the activity of antioxidant enzymes such as SOD and catalase, thereby mitigating oxidative damage at the cellular level (Reference Jeong, Cha and Han21)

However, like MMA, false positive results may occur if one has kidney issues