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gradual increase in number of mast cells

As the metabolic pathways related to homocysteine became delineated other important polymorphic variants were described, such as the thermolabile variant of the folate metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR) (5, 6)

Primarily, it's used in weight loss and thermogenic supplements to help the body burn more calories and support a higher metabolic rate, working by transforming energy-storing white fat cells into heat-generating brown fat cells