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In line with this preclinical evidence, clinical studies have shown that bone-related hormones and BTM display circadian variations, while circadian rhythms disturbances such as working night shifts and/or sleeping disorders have been associated with impaired bone metabolism, reduced bone mass and increased fracture risk (Reference Swanson, Kohrt and Buxton20)

For severe symptoms, seek medical help

No drug-related serious adverse events occurred, and withdrawal rates due to adverse effects were comparable to placebo groups

Instead, it reveals two distinct approaches to the same problem, each with advantages in specific contexts

In reality, combining both methods yields the best results