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Increased expression of NLRP3 and caspase-1 genes in peripheral blood mononuclear cells (PBMC) and elevated protein levels of NLRP3, caspase-1, and IL-1B in the blood plasma were found to correlate with PD severity (40), further supporting the perception of PD as a chronic systemic inflammatory disease

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In the foundational characterization work by Raun and colleagues, Ipamorelin was described as the first GHRP to release growth hormone with a potency and specificity comparable to GHRP-6 but without the accompanying cortisol and prolactin rise