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However, higher doses extend the duration of receptor occupancy and downstream signaling because more peptide molecules are available to bind receptors over the clearance window

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10.1016/j.omtn.2019.03.008 187 ZhangL.YuZ.QuQ.LiX.LuX.ZhangH

W-T., Benyon, R

Together, our complementary omics analyses of eWAT in obese mice reveal a striking tissue remodelling and metabolic reprogramming upon an IF regimen, whereas eWAT seems refractory to most of these IF-mediated changes when p53 is depleted in adipocytes