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The tissue oxygen levels directly affect PDT treatment efficiency, while oxygen levels are widely related to tissue density, and particularly in the deeper part, act as a limiting factor

For those living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), mast cell activation syndrome (MCAS), and dysautonomia, this profound exhaustion and cognitive dysfunction is an all-too-familiar reality

Beyond iron overload, whether iron depletion modulates ferroptosis thresholds by impairing mitochondrial respiratory chain complexesaffecting membrane potential and ROS generationrequires validation using conditional iron transporter knockout, iron chelators, and real-time mitochondrial monitoring (123, 124)

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An energetic view of stress: focus on mitochondria