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Patients who maintain adequate glutathione status during rapid weight loss report fewer subjective complaints and better preservation of lean mass, but the weight loss trajectory itself remains determined by caloric deficit and tirzepatide's appetite-suppressing mechanism

doi: 10.1007/s11606-015-3390-7 130

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Effect of plasma-derived extracellular vesicles on erythrocyte deformability in polymicrobial sepsis

However, glutathione levels can get depleted and can have numerous detrimental effects, including impaired immune function and increased susceptibility to xenobiotics and oxidants