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Given this complex landscape, it becomes clear why just reaching for a B12 shot without understanding the root cause might not be the magic bullet you hope for

However, for the right person, it may reduce pain and improve day-to-day function for a period of time

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The MR finding was OR 1.08 (1.001.16) per 150 pmol/L increase in genetically predicted B12 for overall lung cancer, with the strongest signal for adenocarcinoma (OR 1.23, 1.111.37), the most common subtype to be diagnosed in people who have never smoked (Patel, 2026)