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Activated Caspase-3 cleaves gasdermin E (GSDME), releasing its N-terminal pore-forming domain (PFD) from the C-terminal inhibitory structure, thereby forming membrane pores and inducing GSDME-mediated pyroptosis (46)

Signs of deficiency may include: Megaloblastic anemiaa condition of larger than normal red blood cells and a smaller than normal amount

3.2.4 Akkermansia muciniphila Akkermansia muciniphila , a Gram-negative anaerobic bacterium, specifically colonizes the intestinal mucus layer, critically modulating the microbiota-host inflammatory response-intestinal barrier axis

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