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A 2015 pilot crossover study (N=24) in healthy volunteers taking 1,200 mg/day ALA for 8 weeks found a statistically non-significant trend toward reduced free T3 (mean reduction 0.18 pg/mL, P = 0.08) without TSH elevation [4]

also showed that patients with ischemic stroke ( n = 196) who developed post-stroke depression ( n = 56) two months post-stroke had higher serum ferritin levels at admission compared to those with no depression, with a significant association between both serum ferritin levels and depression [118]

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