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In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation

These patches are known to contain some natural products

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The effectivity of BBB-specific cellular internalization and permeability can be increased by the combination of different targeting ligands on the surface of nanocarriers