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Chronic low-grade inflammation is a genuine pathological feature of PCOS, and emerging research on the gut-ovary-brain axis suggests that gut microbiome dysbiosis may contribute to hypothalamic GnRH dysregulation

Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destre A, Hennekam RC, Arn PH, Curry CJ, Van Laer L, McCallion AS, Loeys BL, Dietz HC

el AHK-Cu tiene datos especficos en folculo, pero in vitro / ex vivo menos maduros