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Without adequate activity, the freed fatty acids may simply be re-esterified and stored again

This often includes patients with: Pernicious anemia, a condition where the body cannot absorb B12 due to a lack of intrinsic factor, a protein produced in the stomach

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Kim H.-J., Cho M.-H., Shim W.H., Kim J.K., Jeon E.-Y., Kim D.-H., Yoon S.-Y

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The export of cholesterol from the lysosomal lumen by NPC1 is essential for the regulation of mTORC1 signalling, thus mutations resulting in the inactivation of NPC1 will not only result in the accumulation of cholesterol but also as the hyperactivation of mTORC1, whose activation is often associated with cancer [39]