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Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism

This entire process prevents the cell from producing misfolded or altered proteins.[ref] Studies show that high homocysteine levels cause ER stress and activate the unfolded protein response pathway, which can lead to cell death

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Transferrin receptor is a specific ferroptosis marker

In the livers of mice fed HFD for 12 weeks, Western diet (WD) for 16 weeks, or WD/CCl 4 for 12 and 24 weeks, the expression of GSTA1 was inversely related to the level of perilipin 2 (PLIN2) (Figure 2D), which is one of the constitutively and ubiquitously expressed proteins homing to the lipid droplets and was used as a protein marker for lipid droplets [18,19]