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doi: 10.3390/antiox7080102 154 IqbalAYabutaYTakedaTNakanoYShigeokaS

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The primary nad+ benefits are bioenergetic and genomic rather than structural: Mitochondrial function: NAD+ is required for the Krebs cycle and electron transport chain

One-carbon metabolism is essential for DNA methylation and synthesis, with methionine serving as the main methyl group donor

It also facilitates intracellular transport along microtubules, which is vital for synaptic function and cellular maintenance