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Avoid repeated warming, cooling, or freezethaw cycles, as temperature fluctuations may affect stability

The reality check: the FDA does not consider it a legal cosmetic or dietary ingredient, and there is real concern that long-term use raises the risk of melanoma (skin cancer) the opposite of what most people assume a tan in a vial would do for skin safety (WebMD)

First, confirm these are purging-type lesions in your typical problem areas

Refrigerate at 4 C (39 F) immediately upon receipt and during active use

Interactions with Medications Vitamin B12 has the potential to interact with certain medications, including diabetic prescriptions, metformin, proton pump inhibitors, antagonists and antibiotics