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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

What were reading Rolling thunder: Inside conservatives strategy to curb abortion pill access, Politico Its all cronyism going forward, The Atlantic Francis Collins blasts Trump administrations slash-and-burn actions at science agencies, STAT Trumps NIH axed research grants even after a judge blocked the cuts, internal records show, ProPublica The state of antibiotic development: Deplorable comes to mind, STAT

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10.2174/13816128130105 27 DjakovicZ.DjakovicI.CesarecV.MadzaracG.BecejacT.ZukanovicG.et al (2016)

1 It has an estimated prevalence of roughly 6% in the UK