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The measurement of paracellular permeability is usually quite straightforward since the movement of ions and charged organic molecules can be measured as an electrical current and the movement of neutral molecules can be measured by assaying their concentration in the bloodstream or urine or in a compartment equivalent to the subepithelial space in mounted or perfused tissue or in cultured cells grown on permeable substrates
Instead, BPC-157 appears to upgrade minor vessels to assume the functions of blocked major vessels
Similar methods were used for cystic fibrosis (CF), a disease characterized by significant pulmonary and pancreatic dysfunctions and is a result of mutations in the CFTR gene, coding for a Cl - channel [87]
171 Furthermore, given the chronic and recurrent nature of IBD, long-term studies are required to assess the safety and therapeutic durability of peptide-based treatments
