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The disruption of these barriers has been observed in ALS patients with spinal cord or motor-cortex accumulation of proteins like fibrin and thrombin [109], reduced levels of TJ proteins, erythrocytes, haemoglobin and hemosiderin, which further cause generation of ROS, toxic to motor neurons (Fig

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Catalase also demonstrates peroxidatic activity, in which low molecular weight alcohols can serve as electron donors, while the aliphatic alcohols serve as specific substrates

Schneider and Zernicke, 1988

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