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Consistent with the NAPstar response, we observed almost no HyPer7 response in glucose-fed cells, except at the highest H 2 O 2 concentration, suggesting that HeLa cells can very efficiently remove H 2 O 2 as long as reductant can be efficiently delivered by metabolism

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Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219

Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis